Nanoparticle Formulation Increases Oral Bioavailability of Poorly Soluble Drugs: Approaches, Experimental Evidences and Theory
نویسندگان
چکیده
منابع مشابه
Pharmaceutical Technologies for Enhancing Oral Bioavailability of Poorly Soluble Drugs
The oral bioavailability of BCS (biopharmaceutics classification system) class II drugs with poor solubility and reasonable permeability is limited by the drug dissolution step from drug products. Though prodrug approach is an exciting way of improving the oral bioavailability, it requires extensive studies to establish the safety profile of prodrugs in humans. In view of the increasing market ...
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Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug ...
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A major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. If the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. Although some approaches are available for enhancing th...
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Lipid-based formulations encompass a diverse group of formulations with very different physical appearance, ranging from simple triglyceride vehicles to more sophisticated formulations such as self-emulsifying drug delivery systems (SEDDS). Lipid-based drug delivery systems may contain a broad range of oils, surfactants, and co-solvents. They represent one of the most popular approaches to over...
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The percentage of new chemical entities synthesised with low aqueous solubility and high therapeutic efficacy is growing, this presents a major challenge for the drug delivery. To over come this challenge, different methods were developed for the improvement of oral bioavailability, but some have major disadvantages. Recently, oral lipid based formulation is developed for the improvement of ora...
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ژورنال
عنوان ژورنال: Current Nanoscience
سال: 2005
ISSN: 1573-4137
DOI: 10.2174/157341305774642939